VEXAS and Related Syndromes Share Immune Signatures

• Health
• Mar 13, 2025

TOPLINE: Shared inflammatory signatures in vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome, myelodysplasia cutis (MDS-cutis), and Sweet syndrome (SS) suggest interferon pathways as therapeutic targets. METHODOLOGY: Multicenter translational study in France compared 20 patients with cutaneous lesions (median age 67 years; 50% men) with five healthy control skin samples...